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Vytorin Side Effects

Before delving into the Vytorin side effects, here's a little background information. Vytorin is a combination of two cholesterol-lowering medications - Simvastatin and Ezetimibe. Because they both work in different ways he conventional thinking is that the combination of both will increase lipid-lowering efficiency more (and better) than just using either of them alone. Another advantage of using the combination drug is that you only have to take one medication as opposed to two and this goes a long way in ensuring increased compliance with taking the medication.

Commonly Occuring Vytorin Side Effects

  • Diarrhea
  • Headache
  • Increased ALT - ALT is a type of liver enzyme
  • Influenza
  • Myalgia - muscle pain
  • Pain in arms and legs
  • Upper respiratory tract infection

Other Vytorin side effects that were observed were reported according to the individual causative agent, either Ezetimibe (Zetia) or Simvastatin (Zocor). You can look up each one of these medications elsewhere on this site for a recap of their side effects.

Post-Marketing Vytorin Side Effects

These side effects were reported after Vytorin was approved and being used by the general population. You should note though that they were reported voluntarily by folks in the general population so there is therefore no way to determine how often they occur or if there is even really a true connection between them and Vytorin.

  • A variety of skin changes (e.g., nodules, discoloration, dryness of skin/mucous membranes, changes to hair/nails)
  • Alopecia
  • Anemia
  • Arthralgia - joint pain
  • Cholecystitis - gallbladder inflammation
  • Cholelithiasis - gall stones
  • Depression
  • Dizziness
  • Elevated creatine phosphokinase - a type of liver enzyme
  • Elevations in liver transaminases - a type of liver enzyme
  • Hepatic failure - liver failure
  • Hepatitis/jaundice
  • Hypersensitivity reactions, including anaphylaxis, angioedema, rash, and urticaria
  • Memory impairment
  • Muscle cramps
  • Myalgia - muscle pain
  • Myopathy/rhabdomyolysis
  • Nausea
  • Pancreatitis
  • Paresthesia - numbness/tingling feeling; "pins and needles" sensation
  • Peripheral neuropathy - numbness, tingling and/or pain in the fingers and toes
  • Pruritus - itching
  • Skin changes (e.g., nodules, discoloration, dryness of skin/mucous membranes, changes to hair/nails)
  • Thrombocytopenia - low platelet count
  • Vomiting

Also note that an apparent hypersensitivity syndrome has been reported rarely that has included one or more of the following features: anaphylaxis, angioedema, lupus erythematous-like syndrome, polymyalgia rheumatica (pain and stiffness in multiple joints), dermatomyositis (a disorder affecting the skin and muscle tissues), vasculitis (inflammation of a blood vessel), purpura (bleeding under the skin), thrombocytopenia (low platelet count), leukopenia (a type of low white blood cell count), hemolytic anemia, positive Anti-Nuclear Antibody (ANA) test, increase in Erythrocyte Sedimentation Rate (ESR), eosinophilia (a type of low white blood cell count), arthritis, arthralgia (joint pain), urticaria (hives), asthenia (general muscle weakness and abnormal loss of muscle strength), photosensitivity (sensitivity to light), fever, chills, flushing, malaise, dyspnea (difficulty breathing), toxic epidermal necrolysis, erythema multiforme, including Stevens-Johnson syndrome.


What some call health, if purchased by perpetual anxiety about diet,
isn't much better than tedious disease.

- George Dennison Prentice


Drug Manufacturer Information

Merck & Co., Inc. AND Schering-Plough Pharmaceuticals

Merck & Co., Inc.
One Merck Drive
P.O. Box 100
Whitehouse Station, NJ 08889-0100
908-423-1000

Schering-Plough Pharmaceuticals
2000 Galloping Hill Road
Kenilworth, N.J. 07033-0530
908-298-4000

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October 11, 2009


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