Metformin Side Effects
Glucopahge XR & Glucophage Side Effects

Aside from the Metformin side effects discussed below, there is a Black Box Warning for Glucophage (Metformin) regarding its potential to cause lactic acidosis. Lactic acidosis is a very serious, though rare metabolic complication that can happen when Metformin accumulates in the body during treatment with either Glucophage or Glucophage XR.

If and when lactic acidosis occurs, approximately 50% of cases are fatal. This condition is considered to be a medical emergency and must be treated in a hospital setting. Fortunately, clinical trials and overall data to date show that the incidence of this condition is extremely low.

Glucophage (Metformin) is used to treat Type 2 Diabetes. Side effects can occur at any time during treatment but usually occur soon after treatment is initiated.

Glucophage - Metformin Side Effects - Common

• Abdominal discomfort
• Asthenia - general weakness/muscle weakness with lack of strength and energy
• Diarrhea
• Flatulence - excessive gas
• Headache
• Indigestion
• Nausea/Vomiting

Glucophage - Metformin Side Effects - Rare

• Abnormal stools
• Chest discomfort
• Chills
• Dyspnea - difficulty/painful breathing; shortness of breath
• Flu syndrome
• Flushing
• Hypoglycemia - low blood sugar
• Increased sweating
• Lightheadedness
• Myalgia - muscle pain
• Nail disorder
• Palpitations
• Rash
• Taste disorder

Glucophage XR Side Effects - Common

• Diarrhea
• Nausea/Vomiting

Glucophage XR Side Effects - Rare

• Abdominal distention
• Abdominal pain
• Constipation
• Dizziness
• Dyspepsia/heartburn
• Flatulence - excessive gas
• Headache
• Taste disturbance
• Upper respiratory infection

The body never lies
- Martha Graham

Drug Manufacturer Information

Bristol-Myers Squibb
345 Park Avenue
New York, New York 10154
800-321-1335 (US only)
609-897-6669

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February 13th, 2010